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brl37344 sodium salt  (Tocris)


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    Tocris brl37344 sodium salt
    β 2 -AR agonists exert proneurogenic effects on ahNPCs. (A) Representative confocal images of MAP-2 (red) and nestin (green) immunolabeling in ahNPCs after 24 h treatment with vehicle (left panel) and 10 nM salmeterol (right panel). Nuclei were stained with DAPI (blue). MAP-2 + /nestin − cells are indicated (arrowheads). Magnification 400X, scale bar = 20 µm. (B-C) Effects of β 2 -AR agonists salmeterol (0.1–10 nM) (B) and formoterol (0.01–10 nM) (C) on neuronal differentiation of ahNPCs. (D-E) Effects of 24-h treatment with salmeterol (SAL) and formoterol (FORM) on GFAP + (D) and NG-2 + (E) cells. (F) Effect of 3 nM SAL in presence of vehicle, ICI118551, SR59230A, or CGP20712 antagonists. (G) Effects of 1 µM NE, 10 nM SAL, 10 nM FORM, and 100 nM <t>BRL37344</t> (BRL) on neuronal differentiation of ahNPCs derived from β 2 -AR knockout mice. (H) Effects of salmeterol (0.0001–1 µM) on ahNPC proliferation. Fold change compared to vehicle-treated (−) ahNPCs. All experiments (n = 3) were run in triplicates. Data are expressed as mean ± S.D. ** p < 0.01, *** p < 0.001 vs. vehicle-treated cells; ### p < 0.001 vs. 3-nM SAL-treated cells (one-way ANOVA, Tukey’s post hoc analysis).
    Brl37344 Sodium Salt, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/brl37344+sodium+salt/pmc06751403-37-25-30?v=Tocris
    Average 92 stars, based on 6 article reviews
    brl37344 sodium salt - by Bioz Stars, 2026-08
    92/100 stars

    Images

    1) Product Images from "Salmeterol, a β2 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner"

    Article Title: Salmeterol, a β2 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2019.01000

    β 2 -AR agonists exert proneurogenic effects on ahNPCs. (A) Representative confocal images of MAP-2 (red) and nestin (green) immunolabeling in ahNPCs after 24 h treatment with vehicle (left panel) and 10 nM salmeterol (right panel). Nuclei were stained with DAPI (blue). MAP-2 + /nestin − cells are indicated (arrowheads). Magnification 400X, scale bar = 20 µm. (B-C) Effects of β 2 -AR agonists salmeterol (0.1–10 nM) (B) and formoterol (0.01–10 nM) (C) on neuronal differentiation of ahNPCs. (D-E) Effects of 24-h treatment with salmeterol (SAL) and formoterol (FORM) on GFAP + (D) and NG-2 + (E) cells. (F) Effect of 3 nM SAL in presence of vehicle, ICI118551, SR59230A, or CGP20712 antagonists. (G) Effects of 1 µM NE, 10 nM SAL, 10 nM FORM, and 100 nM BRL37344 (BRL) on neuronal differentiation of ahNPCs derived from β 2 -AR knockout mice. (H) Effects of salmeterol (0.0001–1 µM) on ahNPC proliferation. Fold change compared to vehicle-treated (−) ahNPCs. All experiments (n = 3) were run in triplicates. Data are expressed as mean ± S.D. ** p < 0.01, *** p < 0.001 vs. vehicle-treated cells; ### p < 0.001 vs. 3-nM SAL-treated cells (one-way ANOVA, Tukey’s post hoc analysis).
    Figure Legend Snippet: β 2 -AR agonists exert proneurogenic effects on ahNPCs. (A) Representative confocal images of MAP-2 (red) and nestin (green) immunolabeling in ahNPCs after 24 h treatment with vehicle (left panel) and 10 nM salmeterol (right panel). Nuclei were stained with DAPI (blue). MAP-2 + /nestin − cells are indicated (arrowheads). Magnification 400X, scale bar = 20 µm. (B-C) Effects of β 2 -AR agonists salmeterol (0.1–10 nM) (B) and formoterol (0.01–10 nM) (C) on neuronal differentiation of ahNPCs. (D-E) Effects of 24-h treatment with salmeterol (SAL) and formoterol (FORM) on GFAP + (D) and NG-2 + (E) cells. (F) Effect of 3 nM SAL in presence of vehicle, ICI118551, SR59230A, or CGP20712 antagonists. (G) Effects of 1 µM NE, 10 nM SAL, 10 nM FORM, and 100 nM BRL37344 (BRL) on neuronal differentiation of ahNPCs derived from β 2 -AR knockout mice. (H) Effects of salmeterol (0.0001–1 µM) on ahNPC proliferation. Fold change compared to vehicle-treated (−) ahNPCs. All experiments (n = 3) were run in triplicates. Data are expressed as mean ± S.D. ** p < 0.01, *** p < 0.001 vs. vehicle-treated cells; ### p < 0.001 vs. 3-nM SAL-treated cells (one-way ANOVA, Tukey’s post hoc analysis).

    Techniques Used: Immunolabeling, Staining, Derivative Assay, Knock-Out



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    β 2 -AR agonists exert proneurogenic effects on ahNPCs. (A) Representative confocal images of MAP-2 (red) and nestin (green) immunolabeling in ahNPCs after 24 h treatment with vehicle (left panel) and 10 nM salmeterol (right panel). Nuclei were stained with DAPI (blue). MAP-2 + /nestin − cells are indicated (arrowheads). Magnification 400X, scale bar = 20 µm. (B-C) Effects of β 2 -AR agonists salmeterol (0.1–10 nM) (B) and formoterol (0.01–10 nM) (C) on neuronal differentiation of ahNPCs. (D-E) Effects of 24-h treatment with salmeterol (SAL) and formoterol (FORM) on GFAP + (D) and NG-2 + (E) cells. (F) Effect of 3 nM SAL in presence of vehicle, ICI118551, SR59230A, or CGP20712 antagonists. (G) Effects of 1 µM NE, 10 nM SAL, 10 nM FORM, and 100 nM <t>BRL37344</t> (BRL) on neuronal differentiation of ahNPCs derived from β 2 -AR knockout mice. (H) Effects of salmeterol (0.0001–1 µM) on ahNPC proliferation. Fold change compared to vehicle-treated (−) ahNPCs. All experiments (n = 3) were run in triplicates. Data are expressed as mean ± S.D. ** p < 0.01, *** p < 0.001 vs. vehicle-treated cells; ### p < 0.001 vs. 3-nM SAL-treated cells (one-way ANOVA, Tukey’s post hoc analysis).
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    β 2 -AR agonists exert proneurogenic effects on ahNPCs. (A) Representative confocal images of MAP-2 (red) and nestin (green) immunolabeling in ahNPCs after 24 h treatment with vehicle (left panel) and 10 nM salmeterol (right panel). Nuclei were stained with DAPI (blue). MAP-2 + /nestin − cells are indicated (arrowheads). Magnification 400X, scale bar = 20 µm. (B-C) Effects of β 2 -AR agonists salmeterol (0.1–10 nM) (B) and formoterol (0.01–10 nM) (C) on neuronal differentiation of ahNPCs. (D-E) Effects of 24-h treatment with salmeterol (SAL) and formoterol (FORM) on GFAP + (D) and NG-2 + (E) cells. (F) Effect of 3 nM SAL in presence of vehicle, ICI118551, SR59230A, or CGP20712 antagonists. (G) Effects of 1 µM NE, 10 nM SAL, 10 nM FORM, and 100 nM <t>BRL37344</t> (BRL) on neuronal differentiation of ahNPCs derived from β 2 -AR knockout mice. (H) Effects of salmeterol (0.0001–1 µM) on ahNPC proliferation. Fold change compared to vehicle-treated (−) ahNPCs. All experiments (n = 3) were run in triplicates. Data are expressed as mean ± S.D. ** p < 0.01, *** p < 0.001 vs. vehicle-treated cells; ### p < 0.001 vs. 3-nM SAL-treated cells (one-way ANOVA, Tukey’s post hoc analysis).
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    Image Search Results


    β 2 -AR agonists exert proneurogenic effects on ahNPCs. (A) Representative confocal images of MAP-2 (red) and nestin (green) immunolabeling in ahNPCs after 24 h treatment with vehicle (left panel) and 10 nM salmeterol (right panel). Nuclei were stained with DAPI (blue). MAP-2 + /nestin − cells are indicated (arrowheads). Magnification 400X, scale bar = 20 µm. (B-C) Effects of β 2 -AR agonists salmeterol (0.1–10 nM) (B) and formoterol (0.01–10 nM) (C) on neuronal differentiation of ahNPCs. (D-E) Effects of 24-h treatment with salmeterol (SAL) and formoterol (FORM) on GFAP + (D) and NG-2 + (E) cells. (F) Effect of 3 nM SAL in presence of vehicle, ICI118551, SR59230A, or CGP20712 antagonists. (G) Effects of 1 µM NE, 10 nM SAL, 10 nM FORM, and 100 nM BRL37344 (BRL) on neuronal differentiation of ahNPCs derived from β 2 -AR knockout mice. (H) Effects of salmeterol (0.0001–1 µM) on ahNPC proliferation. Fold change compared to vehicle-treated (−) ahNPCs. All experiments (n = 3) were run in triplicates. Data are expressed as mean ± S.D. ** p < 0.01, *** p < 0.001 vs. vehicle-treated cells; ### p < 0.001 vs. 3-nM SAL-treated cells (one-way ANOVA, Tukey’s post hoc analysis).

    Journal: Frontiers in Pharmacology

    Article Title: Salmeterol, a β2 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner

    doi: 10.3389/fphar.2019.01000

    Figure Lengend Snippet: β 2 -AR agonists exert proneurogenic effects on ahNPCs. (A) Representative confocal images of MAP-2 (red) and nestin (green) immunolabeling in ahNPCs after 24 h treatment with vehicle (left panel) and 10 nM salmeterol (right panel). Nuclei were stained with DAPI (blue). MAP-2 + /nestin − cells are indicated (arrowheads). Magnification 400X, scale bar = 20 µm. (B-C) Effects of β 2 -AR agonists salmeterol (0.1–10 nM) (B) and formoterol (0.01–10 nM) (C) on neuronal differentiation of ahNPCs. (D-E) Effects of 24-h treatment with salmeterol (SAL) and formoterol (FORM) on GFAP + (D) and NG-2 + (E) cells. (F) Effect of 3 nM SAL in presence of vehicle, ICI118551, SR59230A, or CGP20712 antagonists. (G) Effects of 1 µM NE, 10 nM SAL, 10 nM FORM, and 100 nM BRL37344 (BRL) on neuronal differentiation of ahNPCs derived from β 2 -AR knockout mice. (H) Effects of salmeterol (0.0001–1 µM) on ahNPC proliferation. Fold change compared to vehicle-treated (−) ahNPCs. All experiments (n = 3) were run in triplicates. Data are expressed as mean ± S.D. ** p < 0.01, *** p < 0.001 vs. vehicle-treated cells; ### p < 0.001 vs. 3-nM SAL-treated cells (one-way ANOVA, Tukey’s post hoc analysis).

    Article Snippet: The following drugs were utilized: L-(-)-norepinephrine-(+)-bitartrate salt monohydrate (NE) purchased from Sigma–Aldrich (Milan, Italy), salmeterol xinafoate, formoterol hemifumarate, ICI118,551 hydrochloride, CGP20712 dihydrochloride, SR59230A hydrochloride, and BRL37344 sodium salt purchased from Tocris (Bioscience, Bristol, UK).

    Techniques: Immunolabeling, Staining, Derivative Assay, Knock-Out